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Present research reveals that TAM receptor activation can inhibit immune activity downstream through various pathways, including MEK/ERK, PI3K/AKT, and JAK/STAT pathways (257)

Appl Microbiol Biotechnol 104:71877200

Ex vivo in skin fibroblasts from adolescents with diabetic angiopathy, irbesartan, a selective antagonist of AT1 receptor, increased the enzymatic activity and mRNA expression of antioxidative enzymes: CuZnSOD, MnSOD, CAT, GSH-Px and reduced lipid peroxidation and MDA levels (45)